肖 琼

职称：副教授

性别：男

毕业院校：华侨大学

学位：工学博士

所在单位：海洋食品与生物工程学院

入职时间：2020.09.30

学科：生物工程、食品科学与工程

办公地点：灿英楼118

通讯地址：福建省厦门市集美区印斗路43号

E-mail: xiaoqiong129@jmu.edu.cn

个人简介

工学博士，副教授，硕士生导师，福建省高层次人才，福建省科技特派员。主要从事食品科学、生物化工等领域科研工作，目前主要研究兴趣为：多糖的高值化加工；多糖分子动力学模拟；生物磁珠及微球的制备及应用等。近年来，以第一作者或通讯作者在国内外食品和生物领域高水平期刊发表学术论文30篇，包括中国科学院SCI分区2区及以上收录论文24篇。授权国家发明专利30余件。

教育经历

[1] 2017.09-2020.06  华侨大学|化学工程与技术|工学博士

[2] 2013.09-2015.06  集美大学|食品工程|工程硕士

[3] 2008.09-2013.06  江西农业大学|食品工程与科学|工学学士

工作经历

[1] 2022.09-至今  集美大学|海洋食品与生物工程学院|副教授

[2] 2020.09-2022.08  集美大学|海洋食品与生物工程学院|讲师

[3] 2015.07-2020.09  绿新（福建）食品有限公司|国家红藻加工技术研发专业中心|工程师

研究方向

[1] 海藻多糖的绿色提取及精深加工研究

致力于实现琼脂、卡拉胶的绿色清净生产，实现生化琼脂及琼脂糖的国产化替代。

[2] 生物磁珠及微球的生产及应用技术研究

致力于开发用于生物医药、分析检测及体外诊断等领域的磁珠微球产品。

代表性科研项目

[1] 国家自然科学基金委员会，青年项目，32201941，琼脂基Pickering乳液稳定剂的理性设计及稳定机理研究，2023.01.01-2025.12.31，30万，在研，主持

[2] 国家自然科学基金委员会，面上项目，22278173，过氧化氢选择性催化琼脂脱硫反应机制研究，2023.01.01-2025.12.31，54万，在研，参与

[3] 福建省自然科学基金面上项目，2021J01834，琼脂基Pickering乳液稳定剂的可控制备及作用机理研究，2021.11.01-2024.11.01，7万，在研，主持

[4] 福建省教育厅中青年科技项目，JAT200281，新型功能化琼脂的关键技术开发，2021.01.01-2023.12.31，1万，在研，主持

[5] 集美大学科研启动项目，ZQ2020029，琼脂糖基自组装体Pickering乳液稳定剂的可控制备技术及作用机理研究，2020.11.01-2025.11.30，50万，在研，主持

代表性科研论文

一、提出海藻多糖的水热液化同步提取脱硫理论，建立了琼脂、卡拉胶的绿色提取技术

[1] Qiong Xiao (肖琼), Xiaole Yin, Ding An, Jun Chen, Fuquan Chen, Yonghui Zhang, Huifen Weng, Anfeng Xiao*. Development of a novel agar extraction method using calcium hydroxide and carbon dioxide. Algal Research, 2023, 69, 102933.

[2] Qiong Xiao (肖琼), Xinyi Wang, Jiabin Zhang, Yonghui Zhang, Jun Chen, Fuquan Chen, Anfeng Xiao*. Pretreatment techniques and green extraction technologies for agar from Gracilaria lemaneiformis. Marine Drugs, 2021, 19, 617.

[3] Qiong Xiao (肖琼), Huifen Weng, Hui Ni, Qinglin Hong, Kunhui Lin, Anfeng Xiao*. Physicochemical and gel properties of agar extracted by enzyme and enzyme-assisted methods. Food Hydrocolloids, 2019, 87, 530-540.

[4] Huijing Chen^#, Qiong Xiao^# (肖琼), Weng Huifeng, Yonghui Zhang, Qiuming Yang, Anfeng Xiao*. Extraction of sulfated agar from Gracilaria lemaneiformis using hydrogen peroxide-assisted enzymatic method. Carbohydrate Polymers, 2020, 232, 115790. (#共同一作)

[5] Yao Liu^#, Ding An^#, Qiong Xiao (肖琼), Fuquan Chen, Yonghui Zhang, Huifen Weng, Anfeng Xiao*. A novel κ-carrageenan extracting process with calcium hydroxide and carbon dioxide. Food Hydrocolloids, 2022, 127, 107507.

[6] Feng Jiang^#, Yao Liu^#, Qiong Xiao (肖琼), Fuquan Chen, Huifen Weng, Jun Chen, Yonghui Zhang*, Anfeng Xiao*. Eco-friendly extraction, structure, and gel properties of ι-carrageenan extracted using Ca(OH)₂. Marine Drugs, 2022, 20, 419.

二、提出国产龙须菜琼脂糖的非均相脱硫理论，建立了凝胶电泳级国产替代琼脂糖及其衍生产品的生产技术

[1] Qiong Xiao, Ding An, Chong Zhang, Huifen Weng, Yonghui Zhang, Fuquan Chen, Anfeng Xiao*. Agar quality promotion prepared by desulfation with hydrogen peroxide. International Journal of Biological Macromolecules, 2020, 145, 492-499.

[2] Feng Jiang, Xinwei Xu, Fuquan Chen, Huifen Weng, Jun Chen, Yi Ru, Qiong Xiao* (肖琼, 通讯作者), Anfeng Xiao*. Extraction, modification and biomedical application of agarose hydrogels: a review. Marine Drugs, 2023, 21, 299.

[3] Ding An, Qiong Xiao (肖琼), Cong Zhang, Menghao Cai, Yonghui Zhang, Huifen Weng, Fuquan Chen, Anfeng Xiao*. Preparation, characterization, and application of high-whiteness agar bleached with hydrogen peroxide. Food Hydrocolloids, 2021, 113, 106520.

[4] Cong Zhang^#, Ding An^#, Qiong Xiao (肖琼), Fuquan Chen, Yonghui Zhang, Huifen Weng, Anfeng Xiao*. Convenient agarose preparation with hydrogen peroxide and desulfation process analysis. Marine Drugs, 2021, 19, 297.

[5] Cong Zhang^#, Ding An^#, Qiong Xiao (肖琼), Huifen Weng, Yonghui Zhang, Qiuming Yang, Anfeng Xiao*. Preparation, characterization, and modification mechanism of agar treated with hydrogen peroxide at different temperatures. Food Hydrocolloids, 2020, 101, 105527.

三、提出均相及非均相体系琼脂结构的定点调控理论，建立了多元化食品级及生化级琼脂生产技术

[1] Liling Fu, Yi Ru, Jinming Ye, Qinglin Hong, Huifen Weng, Yonghui Zhang, Jun Chen, Anfeng Xiao*, Qiong Xiao* (肖琼, 通讯作者). Active packaging coating based on agarose grafted with benzoic acid derivatives: Preparation, characterization and application in fish preservation. Food Hydrocolloids, 2024, 153, 110002.

[2] Liling Fu, Qiong Xiao* (肖琼, 通讯作者), Yi Ru, Qinglin Hong, Huifen Weng, Yonghui Zhang, Jun Chen, Anfeng Xiao*. Bio-based active packaging: Gallic acid modified agarose coatings in grass carp (Ctenopharyngodon idellus) preservation. International Journal of Biological Macromolecules, 2024, 255, 128196.

[3] Liling Fu, Yi Ru, Qinglin Hong, Yonghui Zhang, Huifen Weng, Qiuming Yang, Qiong Xiao* (肖琼, 通讯作者), Anfeng Xiao*. Active packaging coatings based on agarose caffeate: Preparation, characterisation, and application in grass carp (Ctenopharyngodon idellus) preservation. Food Packaging and Shelf Life, 2023, 37, 101089.

[4] Zizhou Chen, Guanglin Liang, Yi Ru, Huifen Weng, Yonghui Zhang, Jun Chen, Qiong Xiao* (肖琼, 通讯作者), Anfeng Xiao*. Media-milled agar particles as a novel emulsifier for food Pickering emulsion. International Journal of Biological Macromolecules, 2023, 253, 127185.

[5] Zizhou Chen, Yanhong Xu, Zhechen Xiao, Yonghui Zhang, Huifen Weng, Qiuming Yang, Qiong Xiao* (肖琼, 通讯作者), Anfeng Xiao*. A novel Pickering emulsion stabilized by rational designed agar microsphere. LWT - Food Science and Technology, 2023,181, 114751.

[6] Qiong Xiao (肖琼), Zizhou Chen, Mingze Ma, Xiangji Xie, Huifen Weng, Yonghui Zhang, Jun Chen, Anfeng Xiao. Synthesis, characterization, antibacterial and emulsifying properties of agar benzoate. International Journal of Biological Macromolecules, 2023, 239, 124254.

[7] Qiong Xiao (肖琼), Zizhou Chen, Xiangji Xie, Yonghui Zhang, Jun Chen, Huifen Weng, Fuquan Chen, Anfeng Xiao*. A novel Pickering emulsion stabilized solely by hydrophobic agar microgels [J]. Carbohydrate Polymers, 2022, 120035.

[8] Qiong Xiao (肖琼), Ye SiYing, Yonghui Zhang, Jun Chen, Fuquan Chen, HuiFen Weng, AnFeng Xiao*. Gel properties transition from mono-succinylation to cross-linking of agar by attemperation with succinic anhydride. Food Chemistry, 2022, 381, 132164.

[9] Ye SiYing, Yonghui Zhang, Jun Chen, Fuquan Chen, HuiFen Weng, Qiong Xiao* (肖琼, 通讯作者), AnFeng Xiao*. Synthesis and properties of maleic anhydride-modified agar with reversibly controlled gel strength. International Journal of Biological Macromolecules, 2022, 201, 364–377.

[10] Qiong Xiao (肖琼), Guo Chen*, YongHui Zhang, FuQuan Chen, HuiFen Weng, AnFeng Xiao*. Agarose stearate-carbomer940 as stabilizer and rheology modifier for surfactant-free cosmetic formulations. Marine Drugs, 2021, 19, 344.

[11] Qiong Xiao (肖琼), Guo Chen, Yonghui Zhang, Huifen Weng, Menghao Cai, Anfeng Xiao*. Evaluation of a novel self-emulsifiable dodecenyl succinylated agarose in microencapsulation of docosahexaenoic acid (DHA) through spray-chilling process. International Journal of Biological Macromolecules, 2020, 163, 2314-2324.

[12] Qiong Xiao (肖琼), Chunli Liu, Hui Ni, Yanbing Zhu, Zedong Jiang, Anfeng Xiao*. β-Agarase immobilized on tannic acid-modified Fe₃O₄ nanoparticles for efficient preparation of bioactive neoagaro-oligosaccharide. Food Chemistry, 2019, 272, 586-595.

[13] Qiong Xiao (肖琼), Huifeng Weng, Guo Chen*, Anfeng Xiao. Preparation and characterization of octenyl succinic anhydride modified agarose derivative. Food Chemistry, 2019, 279, 30-39.

[14] Qiong Xiao (肖琼), Guo Chen, Anfeng Xiao*. Preparation, characterization, and emulsification properties of agarose fatty acid derivatives with different hydrophobic chains. International Journal of Biological Macromolecules, 2019, 141, 906-918.

[15] Qiong Xiao (肖琼), Qin Yin, Hui Ni, Huinong Cai, Changzheng Wu, Anfeng Xiao*. Characterization and immobilization of arylsulfatase on modified magnetic nanoparticles for desulfation of agar. International Journal of Biological Macromolecules, 2017, 94, 576-584.

[16] Jingjing Fang, Feng Jiang, Xinwei Xu, Qiong Xiao (肖琼), Qiuming Yang, Fuquan Chen*, Anfeng Xiao*. Gelation melioration with synergistic interaction between κ-carrageenan and senna tora gum mixed gel. Food Hydrocolloids, 2024, 149, 109574.

[17] Luyao Zhang, Qiong Xiao (肖琼), Zhechen Xiao, Yonghui Zhang, Huifen Weng, Fuquan Chen*, Anfeng Xiao*. Hydrophobic modified agar: Structural characterization and application in encapsulation and release of curcumin. Carbohydrate Polymers, 2023, 308, 120644.

[18] Luyao Zhang^#, Siying Ye^#, Fuquan Chen, Qiong Xiao (肖琼), Huifen Weng, Anfeng Xiao*. Super absorbent glutaric anhydride-modified agar: Structure, properties, and application in biomaterial delivery. International Journal of Biological Macromolecules, 2023, 231, 123524.

[19] Luyao Zhang, Qiong Xiao (肖琼), Yonghui Zhang, Huifen Weng, Siyuan Wang, Fuquan Chen*, Anfeng Xiao*. A comparative study on the gel transition, structural changes, and emulsifying properties of anhydride-esterified agar with varied degrees of substitution and carbon chain lengths. Food Hydrocolloids, 2023, 141, 108690.

[20] Huijing Chen^#, Fuquan Chen^#, Qiong Xiao (肖琼), Menghao Cai, Qiuming Yang, Huifen Weng, Anfeng Xiao*. Structure and physicochemical properties of amphiphilic agar modified with octenyl succinic anhydride. Carbohydrate Polymers, 2021, 251, 117031.

四、建立国产龙须菜源琼脂糖基凝胶微球的生产及配基技术，构建国产替代琼脂糖微球及琼脂糖磁性微球层析介质产品

[1] Jinming Ye^#，Yi Ru^#，Huifen Weng，Liling Fu，Jun Chen，Fuquan Chen, Qiong Xiao* (肖琼, 通讯作者), Anfeng Xiao*. Rational design of agarose/dextran composite microspheres with tunable core–shell microstructures for chromatographic application. International Journal of Biological Macromolecules, 2024, 263, 130051.

[2] Mingze Ma, Guanglin Liang, Yi Ru, Jun Chen, Yonghui Zhang, Huifen Weng, Anfeng Xiao, Qiong Xiao* (肖琼, 通讯作者). Synthesis and adsorption performance of carboxyl-functionalized magnetic agarose gel microspheres for Cu(II) removal. Journal of Environmental Chemical Engineering, 2024, 12, 112582.

[3] Qiong Xiao (肖琼), Mingze Ma, Jun Chen, Yonghui Zhang, Fuquan Chen, Huifen Weng, Anfeng Xiao*. Preparation of macroporous rigid agarose microspheres by pre-crosslinking with cyclic anhydride. International Journal of Biological Macromolecules, 2022, 222, 41–54.

五、建立酶制剂的发酵生产及固定化技术

[1] Qiong Xiao (肖琼), Yanbing Zhu, Jiajia Li, Changzheng Wu, Hui Ni, Anfeng Xiao*. Fermentation optimization and enzyme characterization of a new ι-Carrageenase from Pseudoalteromonas carrageenovora ASY5. Electronic Journal of Biotechnology, 2018, 32, 26-34.

[2] Jiajia Li^#, Qiong Xiao^# (肖琼), Yufeng Huang, Hui Ni, Changzheng Wu, Anfeng Xiao*. Secondary enzymatic processing for quality improvement of inferior Tieguanyin Oolong Tea. Electronic Journal of Biotechnology, 2017, 28, 87-94.

[3] Anfeng Xiao^#, Qiong Xiao^# (肖琼), Yan Lin, Hui Ni, Yanbing Zhu, Huinong Cai*. Efficient immobilization of agarase using carboxyl-functionalized magnetic nanoparticles as support. Electronic Journal of Biotechnology, 2017, 25, 13-20.

[4] Anfeng Xiao^#, Qiong Xiao^# (肖琼), Qiuming Yang, Hui Ni, Yanbing Zhu, Huinong Cai*. Immobilization of agarase from marine Vibrio onto carboxyl-functioned magnetic nanoparticles. Journal of Nanoscience and Nanotechnology. 2016, 16(9), 10048-10055.

[5] 肖琼. 葡萄酒脱涩工艺研究. 酿酒科技. 2017, 4, 17-25.

[6] 肖琼, 肖安风*, 姚德恒, 朱艳冰, 倪辉, 蔡慧农. 响应面法优化琼胶的酶解条件. 中国食品学报. 2016, 16 (7), 140-148.

[7] 肖琼, 肖安风*, 姚德恒, 朱艳冰, 倪辉, 蔡慧农. 琼胶酶水解工艺条件的优化及产物分析. 中国食品学报. 2015, 15(12), 99-106.

代表性专利

[1] 肖琼, 肖安风, 郭变变. 一种琼脂糖基凝胶微球的制备方法. 专利号: CN202311000004.5, 公开日期: 2023.08.09.

[2] 肖琼, 肖安风, 翁惠芬. 制备琼脂糖的方法及由此制得的琼脂糖. 专利号: CN2023109346235, 公开日期: 2023.07.27.

[3] 肖琼, 马铭泽, 肖安风, 翁惠芬, 陈俊, 陈福泉, 杨秋明. 一种大孔刚性琼脂糖凝胶微球的制备方法. 专利号: CN202211226258.4, 公开日期: 2023.01.17.

[4] 肖琼, 陈姿舟, 肖安风, 翁惠芬, 陈俊, 张永辉, 庄小燕. 一种琼脂粉末乳化剂及其制备方法与应用. 专利号: CN202211257751.2, 公开日期: 2022.12.06.

[5] 肖安风, 陈姿舟, 肖琼, 翁惠芬, 杨秋明, 张永辉, 庄小燕. 一种非溶解型琼脂粉末乳化剂及其制备方法和用途. 专利号: CN202211114733.9, 公开日期: 2022.11.29.

[6] 肖安风, 马铭泽, 肖琼, 杨秋明, 翁惠芬, 陈俊, 陈福泉. 一种抑菌性琼脂及其制备方法和用途. 专利号: ZL202211115567.4, 授权日期: 2023.05.23. 

[7] 肖安风, 叶思莹, 陈福泉, 杨秋明, 肖琼, 张永辉. 一种制备琼脂糖的方法. 专利号: ZL202010986900.3, 授权日期: 2022.09.30.

[8] 肖安风, 张聪, 肖琼, 陈福泉, 张永辉, 杨秋明. 一种制备琼脂糖的方法. 专利号: ZL202010989301.7, 授权日期: 2022.07.19.

[9] 肖安风, 张聪, 叶思莹, 张永辉, 肖琼, 杨秋明, 陈福泉. 一种制备琼脂糖的方法. 专利号: ZL202010986850.9, 授权日期: 2022.07.19.

[10] 陈国, 肖琼, 肖安风.一种琼脂糖基乳化剂及其制备方法和应用. 专利号: ZL201910717803.1, 授权日期: 2021.09.07.

[11] 陈国, 肖琼, 肖安风. 一种调节琼脂糖凝胶透明度的方法. 专利号: ZL201810730413.3, 授权日期: 2021.01.05.

[12] 肖安风, 李佳佳, 肖琼, 倪辉, 蔡慧农, 吴昌正, 朱艳冰. 一种ι-卡拉胶酶的制备方法. 专利号: ZL201610592652.8, 授权日期: 2019.07.09.

[13] 肖安风, 肖琼, 倪辉, 吴昌正, 姜泽东, 蔡慧农, 朱艳冰, 杨秋明, 杜希萍, 许彩云. 一种酶法替代碱法提取江蓠琼脂的制备方法. 专利号: ZL201610026901.7, 授权日期: 2018.03.02.

代表性获奖成果

[1] 第七届全国大学生生命科学竞赛，琼脂糖磁性微球的制备及其在蛋白纯化中的应用，2023年，全国三等奖，指导老师。

[2] 第六届全国大学生生命科学竞赛，基于环状酸酐预交联法的大孔径刚性琼脂糖微球的合成及其功能研究，2022年，全国三等奖，指导老师。

[3] 第五届全国大学生生命科学竞赛，过氧化氢介导琼脂脱硫其机理分析，2021年，福建省三等奖，指导老师。

[4] 肖琼，第三届“做出突出贡献的工程硕士学位获得者”，全国工程专业学位研究生教育指导委员会，2018. 04.

[5] 肖琼，海藻经济多糖改性酶的发酵制备及应用技术开发, 海洋科技进步奖一等奖，上海海洋科学技术奖奖励委员会，2017. 05.

教学及人才培养

[1] 讲授课程：发酵工程、生物工程设备

[2] 集美大学优秀班主任，2023年

[3] 集美大学戴宽南奖教金，2023年