个人简介 福建省高层次人才,厦门市高层次引进人才。主要从事生物工程及食品科学与工程的基础与应用研究,围绕食品营养成分的组成、结构,采用体外及体内模型对其安全性进行评估,并对其营养功能及作用机制进行系统研究。主持、参与多项国家、省部级课题,并与多家企业展开产学研合作,担任福建省科技特派员,团队科技特派员负责人。 承担本科生“生物分离工程(双语)”、“蛋白质化学”,研究生“蛋白质结构与工程”、“分子营养学”等课程,“生物分离工程(双语)” 获批省级一流本科课程。 工作经历 2012年至今 集美大学,海洋食品与生物工程学院 2009年-2012年 Stony Brook University,School of Medicine, 博士后 社会兼职 中国农学会农产品贮藏加工分会第五届委员会 常务委员 福建省海洋功能食品工程技术研究中心 副主任 研究方向 食品营养、天然活性物质、食品生物技术等 (招收生物与医药研究方向博士后) 代表性科研项目(主持) 1. 传统“老菜脯”特征酚类物质形成分子机制及调控的多组学整合研究国家自然基金面上项目 2. 海洋食源性护肤活性物质绿色开发与高效利用协同创新平台项目 福建省科技厅重点项目 3. 棘胸蛙的种质资源的保护与高值化利用 福建省高校产学合作重点项目 4. 抗高原缺氧功能性产品研制及产业化示范 西藏自治区科技计划技术创新引导计划项目 5. 肉苁蓉功能食品加工关键技术研发及应用示范 福建省科技厅对外合作项目 6. 高端滋补营养品产业化关键技术研究 厦门市科技计划项目 7. 棘胸蛙粉片剂的营养解析及生产工艺研究 泉州市科技重点项目 8. 海洋食源性危害物快速检测技术平台建设 福建省财政厅项目 9. 茶色素的提取制备及产业化关键技术开发 横向项目 10. 海洋益生功能生物制剂关键技术研究及产业化 横向项目 11. 依托科技小院的农业硕士培养模式构建与实践 福建省本科高校教育教学研究项目(重大项目) 代表性科研论文(第一及通讯作者) 1. Analysis of changes in volatile metabolites of pickled radish in different years using GC–MS, OAV and multivariate statistics, Food Chemistry 478 (2025) 143760 2. Hyperuricemia insights: Formation, targets and hypouricemic natural products, Food Bioscience, 64 (2025) 105944 3. Identification of Bioactive Compounds from Citri Reticulatae Pericarpium and Evaluation of Their Uric Acid-Lowering Activity, Plant Foods for Human Nutrition, (2025) 10.1007/s11130-025-01337-4 4. A cooperative combination of non-targeted metabolomics and electronic tongue evaluation reveals the dynamic changes in metabolites and sensory quality of radish during pickling, Food Chemistry, 445 (2024) 138886 5. Preparation and identification of antioxidant peptides from Quasipaa spinosa skin through two-step enzymatic hydrolysis and molecular simulation, Food Chemistry, 445 (2024) 138801 6. Structure-activity relationships of antimicrobial phenolic derivatives from Phyllanthus emblica against Streptomyces scabies, Food Bioscience, 58 (2024) 103709 7. Debittering of Emblica (Phyllanthus emblica L.) fruit powder: preparation and biological activity, Food Chemistry: X, 21 (2024) 100853 8. Three dietary phenols from pickled radish improve uric acid metabolism disorder in hyperuricemia mice associated with the altered gut microbiota composition, Food Bioscience, 61 (2024) 104802 9. Pickled radish alleviates the progression of colitis in mice by reducing inflammation and repairing intestinal barrier, Journal of Functional Foods, 123 (2024) 106591 10. Characterization of Anoectochilus roxburghii Bioactive Compounds and Its Inhibition on the Metabolism-Related Enzyme Activities In Vitro, Journal of Food Biochemistry, (2024) 5521656 11. Comparison of lipid composition between Quasipaa spinosa oil and Rana catesbeiana oil and its effect on lipid accumulation in Caenorhabditis elegans. Journal of Oleo Science, 2024, 73, (2), 239-251 12. Docosahexaenoic acid and eicosapentaenoic acid from microalgae: Extraction, purification, separation, and analytical methods, Algal Research, 77 (2024) 103365 13. The what and who of dietary lignans in human health: special attention to estrogen effects and safety evaluation. Journal of Agricultural and Food Chemistry, 2023, 71, 16419−16434 14. Comparative study on the absorption and metabolism of pinoresinol and pinoresinol-4-O-β-D-glucopyranoside in mice. Molecular nutrition & food research, 2023, 67(24), 202300536 15. Dietary phospholipids alleviate diet-induced obesity in mice: which fatty acids and which polar-head. Marine Drugs, 2023, 21, 555 16. Identification of flavonoids in Anoectochilus roxburghii and in vitro inhibition of key enzymes relevant to metabolic syndrome. Food Bioscience, 56 (2023) 103369 17. Isolation, structural characterization and sporicidal properties of Baelezcin A, a novel cyclic lipopeptide from Bacillus velezensis SJ100083 against gray mold. Journal of the Science of Food and Agriculture, 2023, 103 (12), 5916-5926 18. The composition, characterization, and health impacts of human milk lipid medium- and long-chain TAGs. International Journal of Food Science and Technology, 2023,58(12), 6192-6201 19. Several natural phytochemicals from Chinese traditional fermented food-pickled Raphanus sativus L.: Purification and characterization. Food Chemistry: X, 2022, 15: 100390 20. Toward the next-generation phyto-nanomedicines: cell-derived nanovesicles (CDNs) for natural product delivery, Biomedicine & Pharmacotherapy, 2022, 145: 112416 21. Extraction and characterization of cyclic lipopeptides with antifungal and antioxidant activities from Bacillus amyloliquefaciens,Journal of Applied Microbiology, 2022, 133(6), 3573-3584 22. Characterization of xanthine oxidase inhibitory activities of phenols from pickled radish with molecular simulation. Food Chemistry: X, 2022, 14: 100343 23. Three novel dietary phenolic compounds from pickled Raphanus sativus L. inhibit lipid accumulation in obese mice by modulating the gut microbiota composition, Molecular nutrition & food research, 2021, 65: e202000780 24. Isolation, purification, characterization, and immunomodulatory activity analysis of α-Glucans from Spirulina platensis, ACS Omega, 2021, 6(33): 21384–21394 25. Extraction and characterization of phenolic compounds with antioxidant and antimicrobial activities from pickled radish. Food and Chemical Toxicology, 2020, 136: 111050 26. Biological Evaluation of Keggin-type Polyoxometalates on Tyrosinase: Kinetics and Molecular Modeling, Chemical Biology & Drug Design, 2020, 96(5): 1255-1261 代表性专利 1. 一种抑制α-葡萄糖苷酶活性的棘胸蛙多肽及其制备方法和应用, 202211550826.6(已转化) 2. 抑制血管紧张素转化酶活性的棘胸蛙多肽及其制备方法和应用, 202211550351.0(已转化) 3. 一种抑制黄嘌呤氧化酶活性的棘胸蛙多肽及其制备方法和应用, 202211550832.1(已转化) 4. 从余甘子中提取的没食子酸在植物病害防治中的应用, 202210288987.6 5. 一种从余甘子中提取柯里拉京的方法及其应用, 202210290148.8 6. 从余甘子中提取的1-O-没食子酸酰基-β-D-葡萄糖苷在植物病害防治中的应用, 2022102901492- 7. 一种从余甘子中制备槲皮素-7-O-L-鼠李糖苷的方法, 202210053576.9 8. 一种从贝莱斯芽孢杆菌分离环状脂肽Baelezcin A 的方法, 202211302405.1 9. 一种棘胸蛙冻干粉的全流程生产工艺, 202210077850.6(已转化) 10. 一种余甘子脱苦果粉的制备方法, 202210290137.X(已转化) 11. 犬尿酸在改善高脂饮食致血脂异常、肥胖、肠道菌群混乱中的用途, ZL 202011031858.6 12. 一种从螺旋藻中制备丁香酸的方法, ZL 201811392809.8(已转化) 13. 一种从螺旋藻中制备4-羟基肉桂酸的方法, ZL 201811392831.2(已转化) 14. 一种从中华鲎尾中制备犬尿酸的方法, ZL 201610326173.1 15. 一种从盐渍萝卜中制备松脂素的方法, ZL 201510257581.1 16. 一种从盐渍萝卜中制备对羟基苯甲醛的方法, ZL 201510257677.8 其他代表性成果 1. 第八届中国“互联网+”大学生创新创业大赛,国赛铜奖,2022年 2. 农业农村部福建德化棘胸蛙科技小院,项目负责人,2022年 |